Lagarith offers excellent compression, the MSU Lossless Codec and FFV1 are the only codecs that outperform Lagarith in terms of compression.
Lagarith is able to operate in several colorspaces - RGB24, RGB32, RGBA, YUY2, and YV12. Also, Lagarith will never down-sample video, preventing inadvertent quality loss. For DVD video, the compression is typically only 10-30% better than Huffyuv. However, for high Static scenes or highly compressible scenes, Lagarith significantly outperforms Huffyuv. A comparison for various types of video can be found here.
